Anxiety disorders pathophysiology and pharmacological treatment

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anxiety disorders pathophysiology and pharmacological treatment

Anxiety Disorders: Pathophysiology and Pharmacological Treatment by Gerard Emilien

In this book, the discussion of the normal and pathological aspects of anxiety is critically examined. A chapter on the molecular basis of anxiety is included, outlining the potential of such approach in the discovery of novel effective pharmacological interventions. The face validity, predictability and usefulness of animal models in the design of valid new efficacious products are discussed. Separate chapters dedicated to each particular type of anxiety such as generalized anxiety disorder, social phobia, posttraumatic stress disorder, panic and obsessive-compulive disorder are included. This book should be of benefit to psychiatrists, clinical psychologists, general practitioners, nurses, students and all those engaged in neuropsychiatric research.
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Published 10.12.2018

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Modern pharmacological treatments for anxiety disorders are safer and more tolerable than they were 30 years ago. Unfortunately, treatment efficacy and duration have not improved in most cases despite a greater understanding of the pathophysiology of anxiety. Moreover, innovative treatments have not reached the market despite billions of research dollars invested in drug development.
Gerard Emilien

Anxiety Disorders

If your institution subscribes to this resource, and you don't have a MyAccess Profile, please contact your library's reference desk for information on how to gain access to this resource from off-campus. The long-term goal in treatment of generalized anxiety disorder is remission with minimal or no anxiety symptoms and no functional impairment. Antidepressants are the agents of choice for the management of generalized anxiety disorder. Antidepressants have a lag time of 2 to 4 weeks or longer before antianxiety effects occur in generalized anxiety disorder. When monitoring the effectiveness of antidepressants in panic disorder, it is important to allow an adequate amount of time 8 to 12 weeks to achieve full therapeutic response. Clonazepam and alprazolam extended-release are alternatives to alprazolam immediate-release for patients with panic disorder having breakthrough panic symptoms at the end of a dosing interval. The optimal duration of panic therapy is unknown; 12 to 24 months of pharmacotherapy is recommended before gradual drug discontinuation over 4 to 6 months is attempted.

Anxiety disorders are the most prevalent mental health conditions. Although they are less visible than schizophrenia, depression, and bipolar disorder, they can be just as disabling. The diagnoses of anxiety disorders are being continuously revised. Both dimensional and structural diagnoses have been used in clinical treatment and research, and both methods have been proposed for the new classification in the Diagnostic and Statistical Manual of Mental Disorders IV DSM However, each of these approaches has limitations. More recently, the emphasis in diagnosis has focused on neuroimaging and genetic research. This approach is based partly on the need for a more comprehensive understanding of how biology, stress, and genetics interact to shape the symptoms of anxiety.

Shelton CI. Diagnosis and Management of Anxiety Disorders. Major anxiety disorders are more prevalent in women than in men. Although the tendency toward anxiety disorders appears familial, other factors such as environmental influences can play a role in the risk for anxiety. This clinical review focuses on the pathophysiologic basis for anxiety disorders. It provides brief overviews of panic disorder, generalized anxiety disorder, social anxiety disorder, obsessive-compulsive disorder, and posttraumatic stress disorder. It also summarizes treatment options for patients with anxiety disorders.

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It seems that you're in Germany. We have a dedicated site for Germany. Authors: Emilien , G. Anxiety disorders are very common and constitute some of the most frequent psychological problems in medical practice. The term anxiety disorder is used to describe conditions in which pathologic anxiety is the predominant factor. These conditions include phobic disorders, panic disorder, generalized anxiety disorder, posttraumatic stress disorder and obsessive-compulsive disorder.


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